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At the start of the pandemic in March we took the decision to make online access to our news free of charge by taking down our paywall. At a time where accurate information about Covid was vital to our community, this was the right decision — even though it meant a drop in our income. To access all other news will require a subscription, as it did pre-pandemic. The good news is that for the whole of December we will be running a special discounted offer to get 3 months access for the price of one month. Thank you for supporting us during this incredibly challenging time.
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Through protein engineering and a novel pegylation strategy, a diabody specific to tumor-associated glycoprotein 72 TAG PEG-AVP has been created to optimize pharmacokinetics and bioavailability to tumor. The primary study objective of the first-in-human study was the safety of a single protein dose of 1. Secondary study objectives were evaluation of the biodistribution, tumor uptake, pharmacokinetics and immunogenicity. Safety, pharmacokinetics, biodistribution, and immunogenicity were assessed up to 28 days after infusion. Imaging was evaluable in 5 patients, with rapid and highly specific targeting of tumor and minimal normal organ uptake, leading to high tumor:blood ratios. Conclusions: These data demonstrates the safety and feasibility of using pegylated diabodies for selective tumor imaging and potential delivery of therapeutic payloads in cancer patients. Numerous antibody-based cancer therapies have been developed, taking advantage of the specificity of targeting tumor antigens and advances in recombinant protein production technology.
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