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Previous studies have identified over 3, genes that are differentially expressed in male and female skeletal muscle. Here, we review the sex-based differences in skeletal muscle fiber composition, myosin heavy chain expression, contractile function, and the regulation of these physiological differences by thyroid hormone, estrogen, and testosterone. The findings presented lay the basis for the continued work needed to fully understand the skeletal muscle differences between males and females. Cardiac, smooth, and skeletal are the three muscle types in mammals, with skeletal muscle being the most abundant tissue in the human body. Skeletal muscles are composed of different types of fibers which diverge morphologically, biochemically, and functionally. Early studies describing muscle fiber-type composition and development did not address the potential for differences between species and sex.
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Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition

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Metrics details. Body composition differs between men and women, with women having proportionally more fat mass and men more muscle mass. Although men and women are both susceptible to obesity, health consequences differ between the sexes. Men and women were compared by Wilcoxon signed rank test. Linear correlation and multivariate analyses between body composition and cardiometabolic risk markers were performed.
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Sex differences in body composition and association with cardiometabolic risk

Reductions in muscle size and strength occur with aging. These changes can be mitigated by participation in resistance training. At present, it is unknown if sex contributes to differences in adaptation to resistance training in older adults.
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Six young men and six young women were participated in this study. Muscle sample was obtained from vastus lateralis muscle. To examine potential gender differences within each fiber contractile properties CSA, maximal isometric force, SF, maximal shortening velocity and relationship between CSA and SF of single fiber using Pearson correlation.
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